It's possible you'll get drowsy or dizzy. Tend not to generate, use machinery, or do everything that wants psychological alertness until eventually you understand how this medication influences you.

Observational reports have shown that concomitant use of opioid analgesics and benzodiazepines raises the threat of drug-relevant mortality when compared with usage of opioids by itself.

If you're prescribed this medication on an everyday timetable and overlook a dose, get it the moment you keep in mind. If it is close to the time of the following dose, skip the missed dose. Choose your future dose with the standard time. Usually do not double the dose to catch up.

Codeine is understood for being subject to abuse; nonetheless, the abuse possible of oral codeine appears to become very minimal. Even parenteral codeine would not appear to offer the psychic consequences sought by addicts to a similar diploma as heroin or morphine.

g., These with proof of amplified intracranial stress or Mind tumors), Promethazine HCl and Codeine Phosphate Oral Resolution may possibly cut down respiratory travel, plus the resultant CO2 retention can additional improve intracranial stress. Furthermore, opioids generate adverse reactions which could obscure the medical study course of clients with head accidents.

Clearance could possibly be lowered and the metabolites may possibly accumulate to Substantially bigger plasma levels in patients with renal failure as compared to clients with standard renal operate.

Neuroleptic malignant syndrome (NMS) which can cause Dying. Tell you Health care supplier instantly When you have any of the subsequent signs and symptoms of NMS:

The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients under six decades of age, mainly because the combination may possibly induce fatal respiratory depression With this age population (see WARNINGS – Box Warning Promethazine codeine syrup and Use In Pediatric Clients).

The lowest effective dosage should be employed, along with other medicines that have an impact on breathing should be averted. Get healthcare help right away inside the unlikely event that gradual/shallow breathing happens. Promethazine shouldn't be used by young children with liver disease (which includes possible Reyes syndrome).

Promethazine is metabolized with the liver to several different inactive metabolites such as sulfoxides of promethazine, N-demethylpromethazine and other glucuronides.

Opioid cough suppressants shouldn't be used by youngsters more youthful than 18 many years. Youngsters are at larger threat for really serious (even fatal) Unwanted side effects, Specifically respiratory problems. Talk with the doctor regarding the risks and advantages of this medication.Cough-and-cold goods will not get rid of colds. Cough as a result of a typical cold usually does not should be handled with medicine. Inquire your health practitioner or pharmacist about other means To ease cough and chilly signs, like drinking adequate fluids, using a humidifier, or saline nose drops/spray.

This medication might make you far more delicate towards the Solar. Restrict your time in the Sunshine. Keep away from tanning booths and sunlamps. Use sunscreen and wear protective clothes when outside. Notify your health care provider instantly if you have sunburned or have skin blisters/redness.

If someone has overdosed and has significant indicators such as passing out or issues breathing, get in touch with 911. Normally, contact a poison Manage Middle without delay.

Promethazine HCl and Codeine Phosphate Oral Answer might lead to extreme hypotension like orthostatic hypotension and syncope in ambulatory people. There is elevated possibility in clients whose ability to keep up hypertension has by now been compromised by a lowered blood volume or concurrent administration of specific CNS depressant medications (e.